A NEW MODEL MIMICKING PERSISTENT HBV E ANTIGEN-NEGATIVE INFECTION USING COVALENTLY CLOSED CIRCULAR DNA IN IMMUNOCOMPETENT MICE.

A new model mimicking persistent HBV e antigen-negative infection using covalently closed circular DNA in immunocompetent mice.

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem.HBV e antigen (HBeAg)-negative strains have become prevalent.Previously, no animal model mimicked the clinical course of HBeAg-negative HBV infection.To establish an HBeAg-negative HBV infection model, the 3.2-kb full-length genome of

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Decompressive craniectomy in traumatic brain injury: Quo Vadis?

Intracranial hypertension is the leading cause of mortality in patients with cranial injury.Currently Aprons the traumatic brain injury is a public health problem worldwide.Decompressive craniectomy emerges Health as a treatment strategy for patients with refractory intracranial hypertension.The completed surgery requires careful surgical technique

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